Technology Transfer Group, popular as TTG in IIT Kharagpur is the student arm of Sponsored Research and Industrial Consultancy (SRIC), IIT Kharagpur. TTG acts as a vehicle to create IP awareness on R & D activities at IIT Kharagpur. Promotional activities of TTG are found to draw interest of industry in technologies developed at IIT Kharagpur.
Thursday, 18 June 2015
Bone Grafts via Bio-mimetic Approach
Patent Filing No.: 983/KOL/2014
DST Lockheed Martin India Innovation Growth Program Award 2015
Healing of complicated bone fractures, fibrous
non-unions and severe trauma require additional support material as template to
aid the healing process. Material selection and template design depend on
physico-mechanical properties of bone/tissues and their regeneration kinetics.
Calcium phosphate (CaP) based hybrid composite with non-collagenous polymer
(NCP) scaffold becomes a promising approach for bone graft replacement due its
structural and functional characteristics relevant to musculoskeletal tissue.
invention relates to compositional aspect, fabrication strategies and three
dimensional architectural designs towards skeletal tissue healing.
Specifically, synthesis procedure of mono/multiphasic calcium phosphates from
biological wastes, phosphorylation of polymers, their applications individually
or in combinations towards repairing/regeneration of skeletal tissues and other
biomedical means. Besides bioactivity, this hybrid composite containing
inorganic phase will offer high elasticity and organic matrix will provide
resilience and resistance to failure. Therefore depending on the tissue type,
mineral to organic ratio can be altered to match the tissue specific
physico-chemical properties. CaP based composite scaffold with phosphorylated
polymers have pH buffering effect which control degradation and resorption rate
of polymer as well as suppress consecutive acidic degradation. Not only
combination of two different phases, but also their organization can be varied
with analogues to the bone in terms of pore architecture by various scaffold
design approaches. Both the ceramic phase and polymer phase are originated from
biological waste material, transformed in to biologically active/relevant
material in a cost effective way.
Summary of the technical details
Resorbable, multi-scalar hierarchical, hybrid
composite bone graft has been made, comprising of: (a.) an inorganic phase of
multiphasic calcium phosphate (CaP) and its derivative thereof, it is
biocompatible, osteoconductive, osteoinductive, with plurality of highly
interconnected multi-scalar pores. It is synthesized from biological waste
materials (egg shells, sea shells, etc.) in a cost effective single step
sintering process. It is highly interconnected, microstructural scaffold in the
form of 3D printed, fibrous patterned, foam and as spacer. (b.) a second
material is a natural origin resorbable functionalized polymer (phosphorylated
chitosan and its derivative) or polymer selected from the group comprising
polylactic acids, polyglycolic acids, and combinations thereof. Functionalized
chitosan synthesized in a novel, time saving, cost effective, microwave irradiator
method. Polymer phase fabricated in the form of nanofibrous film, microfilm,
fibrous, 3D printed and spacer.
Combination of two phases and their organization
varied with analogues to the targeted bone in terms of microstructure and
Advantages of this technology
(1)Innovation is related to design
and fabrication of composite scaffold via combinatorial approach towards bone
(2)Customized bone graft prepared in
minimal processing steps with cost effective method.
(3)Raw materials for both the phases
are natural origin and biological waste.
(4)Combination of two different
phases and their organization can be varied with analogues to the targeted
(5)Composite scaffolds have
nano-micro architecture with bone like structural hierarchy.
(6)Prepared scaffold is bioactive,
resorbable, osteoinductive and osteogenic.
aspects of the technology & Industries benefiting from it
Every year, 5.8 million people die from orthopaedic
trauma and related injuries, 95% of these deaths occurring in developing
countries. Being a highly populous developing nation, India faces the brunt of
orthopaedic related disease and injuries. Moreover, India spends only 4% of its
GDP on healthcare sector, which is insufficient. On the other hand, the
currently available bone implants are highly expensive and mostly imported.
Therefore, in such low resource settings, we need to come up with alternative
solutions, that are affordable and equally or more effective. Current available
options are slow in healing, required revision surgeries that cause several
associated complications as well.
In this context, we have come up with a ‘HYBRID BONE
GRAFT’ as bone substitute implant from natural origin biological waste, having
rapid integration with host tissue, results in faster healing, following
completely reabsorption and no revision surgeries required. Importantly, it is
prepared via minimum processing steps, can be customized and scalable process
using biological waste, which makes it around 5-10 times less costly and
The technology is available off-the-shelf and it can be
brought to market with nominal investment.